Kinolinsyre er et metabolitt i kynureninveien, som er involvert i metabolismen av aminosyren tryptofan. Den spiller en nøkkelrolle som en eksitotoksin i sentralnervesystemet. Forhøyede nivåer av kinolinsyre har blitt knyttet til nevrologiske tilstander som Alzheimers sykdom, Huntingtons sykdom, epilepsi og visse psykiatriske lidelser, inkludert depresjon.
Testing quinolinic acid levels can be beneficial for individuals with or at risk for certain neurological disorders, such as Alzheimer’s disease, Huntington’s disease, and some forms of epilepsy. It may also be useful for those with psychiatric conditions like depression, where altered kynurenine pathway metabolism is suspected.
Dysregulated quinolinic acid levels, particularly when elevated, can lead to symptoms associated with neurotoxicity and inflammation. These may include:
Several factors can impact quinolinic acid levels:
Regulating quinolinic acid levels involves a holistic approach, focusing on overall health: